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NFT-dependent activation of the Nrf2 pathway elevates cellular resilience Nrf2/Keap1 ranks among the most relevant cellular signaling elements that combine sensing of oxidative stress with transcriptional activation of downstream targets involved in antioxidant defense

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14 Discussion While the herbal formulations and their active compounds, standalone or in combination, have demonstrated robust in vitro efficacy, translation to in vivo and clinical settings remains variable, and oftentimes a large therapeutic barrier

Wang, J., Wolf, R