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It is accompanied by an altered composition and functionality of immune cell subsets including circulating monocytes, dendritic cells (DCs), neutrophils, B cells and T cells along with a state of chronic inflammation (inflammaging) [7]

Some protocols use split dosing to create multiple pulses

(2016) Ergothioneine oxidation in the protection against high-glucose induced endothelial senescence: involvement of SIRT1 and SIRT6

Researchers sometimes combine this lipotropic compound with metabolic peptides like MOTS-C or CJC-1295 in comprehensive protocols

Last reviewed: June 2, 2026 Last updated: June 2, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations