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9 Tamler C, Fonseca RM, Pereira FB, Barcau CB

L.et al (2022a)

What helps with withdrawal

Combining peptides with antidepressants is not universally unsafe, but safety depends entirely on the specific peptide class, the antidepressant mechanism (SSRI, SNRI, MAOI, tricyclic), and whether their receptor pathways overlap

Specifically, diverse alkaloids and saponins have been shown to activate both PPAR and PPAR isoforms