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Other concerning features that warrant prompt medical attention include: new headache onset after age 50, headache during pregnancy or postpartum period, headache with fever or neck stiffness, headache following head trauma, headache in immunocompromised patients, and headache that worsens with position changes or Valsalva maneuver (coughing, straining)

The selectivity is documented in the foundational paper: a peer-reviewed European Journal of Endocrinology study demonstrating that Ipamorelin stimulates growth hormone selectively without elevating ACTH, cortisol, or prolactin, which is exactly why it has become the default selective secretagogue in modern peptide medicine

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Plazier M, Ost J, Stassijns G, De Ridder D, Vanneste S

281 , R1925R1933 (2001)