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That age-related decline is part of what drew sustained scientific attention to the compound in the first place

Moreover, an abundance of iron and susceptibility to oxidative stress have resulted in the hypothesis that erythrocytes might undergo ferroptosis, an iron-driven ROS-dependent RCD [78]

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The agency applied the four-factor framework set out in 21 CFR 216.23(c), covering physical and chemical characterisation, safety, evidence of effectiveness, and historical use