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Semaglutide and tirzepatide are "upstream" they act on incretin receptors to influence appetite regulation, gastric emptying, and glucose-dependent insulin secretion

This leads to fewer breathing interruptions and better overall sleep quality

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The involvement of medicinal chemists will also help delineate the impacts of different structural changes, such as different terminal linkages with GSH ( C -terminal, S -terminal, and N -terminal), on binding selectivity and efficiency, and establish structure-activity relationships (SAR) for the development of glutathione transporter-based brain targeting ligands

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