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For affinity fusion proteins, the appended protein will bind to a third, typically small, molecule that is immobilized on the surface of a polymer resin
Iron has been shown to promote the aggregation and pathogenicity of -amyloid (Rottkamp et al., 2001), tau (Sayre et al., 2000), -synuclein (Xiao et al., 2018) and indirectly, TDP43 (Jeong et al., Importance of Iron Homeostasis Iron is an essential metal for neurons, required for mitochondria respiration as well as other processes e.g., myelination and neurotransmitter synthesis (Ward et al., 2014
A balanced microbiome appears to be essential for healthy brain function, while microbial perturbations can contribute to cognitive deficits, mood disturbances, and neuroinflammation (Sorboni et al., 2022)
Apheresis can also help to remove microvascular blood clotting and has been shown to reduce autoantibodies in ME/CFS, but high costs limit its use (253)