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CYP3A4 Inhibitors: Some medications, such as certain antifungal drugs and antibiotics, can inhibit the enzyme CYP3A4, which is involved in the metabolism of sildenafil

, Prakash, S

US Department of Health and Human Services Food and Drug Administration

doi: 10.1530/ERC-12-0398

As mentioned previously, tumour/cancer cell metabolism is highly variable and is dependent on multiple factors like anatomical location, genetic factors, environmental conditions, lifestyle, pharmacological interventions, physiological conditions impacting the surrounding microenvironment, and availability of nutrients (illustrated in Fig