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For chemogenetic activation, CNO (5 mg kg 1 ) was administrated intraperitoneally 1 h after morphine injection

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FIGURE 2 3 The activation mechanism of eryptosis in renal anemia In the uremic milieu of CKD, a constellation of factorsincluding uremic toxin accumulation, chronic inflammation, oxidative stress, and hypoxiaconverge to induce cellular damage signals that promote eryptosis, the programmed death of erythrocytes

2010 Colonna P, Iliceto S: Myocardial infarction and left ventricular remodeling: results of the CEDIM trial