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This method allowed the goodness of fit to inform upon an appropriate model structure when the actual reaction rates were unknown and, in doing so, provided a useful indication of the possible mechanism by which this process occurs

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There is a risk of developing both local relapses and distant metastases in 2644% of cases, while there were reports that with 5-year follow-up of patients, and only 53% had a stable course of the disease [45, 46]

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