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TRPM3: The Ion Channel Behind Pain, Migraines, and ME/CFSTRPM3 is a calcium ion channel involved in heat sensing, pain transmission, migraines, and immune function

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Common side effects (GLP-1 medications) Nausea Vomiting Diarrhea or constipation Reduced appetite to the point of under-eating Rare but serious risks may include: Pancreatitis Gallbladder issues Growth hormone-related peptides Potential risks: Fluid retention Joint pain Insulin resistance (if misused) Long-term unknowns For newer or research peptides, long-term data is limited

95% CI 1.94 to 1.50

Endocrine/metabolic A new molecule combines the action of two incretins, GLP-1 and GIP, hormones that regulate glucose and appetite, with lanifibranor, a triple agonist of peroxisome proliferator activated receptors (PPAR //)