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Insulin secretion: GLP-1 stimulates insulin release from the pancreas in response to rising blood glucose

One of the mechanisms by which these drugs work is by slowing the digestion of food by slowing gut motility as well as, in the case of the GLP-1/GIP co-agonists, reducing stomach acid

Even the GLP-1 receptor agonist class, which has actual PCOS trial data and long-standing approvals for diabetes and obesity, is used in PCOS only off-label and with explicit acknowledgment of limited evidence

15,16 Database details are in eTable 1 in Supplement 1