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To achieve the enrollment target for the substudy (approximately 100 participants), the main study was overenrolled ( n = 338 versus planned n = 300)

Both weight loss from Wegovy and propranolol can lower blood pressure

Since the active ingredients are different, these medications are not interchangeable

The FDA issued a declaratory order in December 2024 reaffirming this decision and established grace periods for pharmacies to wind down their compounded tirzepatide operations

A recent meta-analysis found GLP-1 drugs lowered the risk of major kidney complications, including in those who had existing heart disease but not diabetes