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Dixon first discovered and named ferroptosis, the critical role of GPX4 in the inhibition of ferroptosis in his study has received widespread attention, mainly in the antioxidant axis system x c - -GSH-GPX4 ( c - is inhibited, obstruction of the cystine transport pathway can decrease GSH and GPX4, which can lead to cell death due to ongoing oxidative stress ( Figure 1A )

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Other effects of activation of GLP-1 receptors include inhibition of glucagon secretion combined with inhibition of gastric emptying, suppression of appetite and cardioprotective effects [5]