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An increase in the abundance of Escherichia-Shigella in the intestine results in a decrease in the expression of the tight junction proteins ZO-1, occludin and claudin-1 and a reduction in mucus secretion, which facilitates the translocation of luminal noxious factors, triggers inflammatory responses and exacerbates intestinal injury, thereby destabilizing the intestinal microenvironment 117
Enhance antioxidant protection and overall cellular function
Gerstein HC, Colhoun HM, Dagenais GR, Diaz R, Lakshmanan M, Pais P, Probstfield J, Riesmeyer JS, Riddle MC, Rydn L, et al: Dulaglutide and cardiovascular outcomes in type 2 diabetes (REWIND): a double-blind, randomised placebo-controlled trial
Anti-Inflammatory Effects: GLP-1 RAs exhibit broad anti-inflammatory properties, reducing oxidative stress and the expression of pro-inflammatory cytokines (e.g., TNF-, IL-6) by inhibiting the NF-B signaling pathway
Use the Taltz autoinjector or syringe only once and inject all the solution in the syringe or autoinjector
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