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Long term prescription of medications such as the following are likely to increase the cause of, or exacerbate the risk of B12 deficiency - the proton pump inhibitors (esomeprazole, lansoprazole, omeprazole, pantoprazole, rabeprazole), famotidine, ranitidine, metformin, glibenclamide, gliclazide, glimepiride, glipizide, sodium valproate, gabapentin, doxycycline, some oral contraceptives

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Previous measures of tirzepatide activation of human incretin receptors demonstrated increased potency at hGIPR relative to hGLP-1R 16

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A., Rillamas-Sun, E., & Jannausch, M