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In contrast, the model group shows a significant reduction in neuron density ( p = 0.0001), highlighting the detrimental effects of sleep deprivation on brain health

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Other symptoms of more severe deficiency include seizures, trouble coordinating movement, and metabolic acidosis, which is a buildup of acid in the body and includes symptoms such as nausea and vomiting (NIH, n.d.)

Effects on mitochondria: Humanin directly improves mitochondrial biogenesis and function [25], while MOTS-c acts via cytosolic and nuclear signalling [1]

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