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A 2025 Bayesian network meta-analysis reported that 10.6% of patients experienced diarrhea while using semaglutide, according to Comparative gastrointestinal adverse effects of GLP-1 receptor agonists and multi-target analogs in type 2 diabetes

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People already questioning whether they can lose weight on semaglutide without exercise or whether the medication is right for them may incorrectly conclude that semaglutide is ineffective when the real problem was a warm shipment

These figures are from controlled clinical trials of the FDA-approved branded medications (Wegovy, Zepbound), combined with diet and exercise