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The network has an average local clustering coefficient of 0.683 and average node degree of 20.6, with a network diameter of 4, radius of 2, a characteristic path length = 1.978, network density = 0.229, and heterogeneity = 0.682

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Experimental studies report activation of signaling mechanisms related to vascular remodeling, including Notch-associated pathways and endothelial cell activation in angiogenesis models [8]

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