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As discussed above, DPP-4 levels are positively correlated with BMI and insulin resistance and, in some studies, also to glycaemic control, but the mechanisms regulating synthesis and release of DPP-4 are still incompletely understood

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The count data were filtered to remove genes with low expression, transformed using the variance stabilizing transformation from the DESeq2 package (51), and then batch corrected using ComBat (52)