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In this context, for instance, the pharmacokinetic profile needs to be defined in detail, including the type of metabolic enzymes involved in its degradation, interactions resulting from the binding of the drug to plasma proteins, etc

Chingizova EA, Yurchenko EA, Chingizov AR, Klimovich AA, Pislyagin EA, Menchinskaya ES

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Several other studies, [97-101] including a meta-analytic review [98] and a retrospective study, [97] suggested that stimulant therapy in childhood is associated with a reduced risk of subsequent substance use, cigarette smoking and alcohol use disorders