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40-360 g/kg, i.p.) increases catalase and superoxide dismutase (SOD) activities and malonic dialdehyde (MDA) concentration in 40 g/kg in the liver homogenate of rats subjected to acute stress, but exhibits the opposite effects at 120 g/kg, and 360 g/kg [2]

Originally introduced to manage blood glucose levels in diabetes patients, these drugs are now recognized for their capacity to drive meaningful weight reduction and deliver broad improvements in metabolic health

Final outlook and conclusions SGLT2i and GLP-1RA exert cardio-renal protection through distinct, primarily glucose-independent pathways, making their combined use a logical strategy to improve cardiometabolic and renal outcomes

Tirzepatides 10 kilograms again led the field