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Role of calcium signaling in prostate cancer progression: effects on cancer hallmarks and bone metastatic mechanisms

Various factors are involved in the progression of DN, such as disorder of oxygen metabolism and lipid metabolism, hyperglycemia, advanced glycosylation products, and inflammatory response [140, 141]

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Third, hyperhomocysteinemia detected both under basal conditions and after a methionine challenge (approximately 50% of patients), which might be partially explained by a saturation of the transsulfuration pathway caused by dietary methionine excess

Even at lower doses, significant weight loss has been observed across multiple studies