The New England Journal of Medicine commentary accompanying SURPASS-2 stated: "The dual incretin approach appears to exploit receptor crosstalk in ways that amplify downstream insulin secretion beyond what GLP-1 receptor agonism alone can achieve at comparable tolerability." [30] SURPASS-1: Monotherapy Benchmark SURPASS-1 (N=478) established monotherapy efficacy, with tirzepatide 15 mg reducing A1C by 2.07 percentage points and body weight by 9.5 kg at 40 weeks versus placebo [31]
Medical Xpress+2JAMA Network+2 Lassociation Cagrilintide + semaglutide (parfois nomme CagriSema ) est ltude : elle pourrait offrir des bnfices encore plus importants sur le poids, le mtabolisme et potentiellement les marqueurs CV ou inflammatoires
Important safety considerations include risk of pancreatitis (seek urgent medical care if you experience severe, persistent abdominal pain), gallbladder problems, and potential hypoglycaemia in people with diabetes taking insulin or sulfonylureas
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However, subtle differences exist based on their secondary receptor targets and clinical trial safety data
