glp-1 alcohol use disorder medications get at the heart of addiction: study – WashU Medicine Can semaglutide help reduce alcohol

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177 In vivo, mitochondrial dynamics-related factor Parkin was significantly reduced in the substantia nigra of a mice fed a high-fat diet and a diabetic mice, leading to the accumulation of Parkin-interacting substrate and the reduction of PGC-1

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Mechanistically, activation of PARP1 in calcified VSMCs elevates POLG PARylation levels, triggering PARylation-dependent ubiquitination and subsequent downregulation of POLG

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