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Lifestyle modifications involving exercise and dietary changes are considered the initial treatments for patients with PCOS and should be incorporated into the patients overall management plan (Mizgier et al., 2021

In both studies, tumour size was measured by an investigator blinded to the treatment groups

There are considerable efforts to design probes that accurately measure types of ROS in different compartments of the cell

The limitation of that study was the small number of patients, but the authors concluded that compared with healthy neonates, the HIE group had increased melatonin, SOD, and NO concentrations, and the combination of melatonin to therapeutic hypothermia in infants with HIE can improve neurodevelopmental outcome at 6 months of age with effective effects in reducing oxidative stress in terms of NO and SOD serum level reduction