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Exenatide, the active ingredient in BYDUREON BCISE, was not mutagenic or clastogenic, with or without metabolic activation, in the Ames bacterial mutagenicity assay or chromosomal aberration assay in Chinese hamster ovary cells

This may suggest that ARA-290 targets specifically the TRPV1 channels and might potentially increase the amount of capsaicin needed to activate these channels

Neurological symptoms (paraesthesia, balance problems, neuropathy) require urgent GP assessment as prolonged deficiency causes irreversible nerve damage

Cardinale JP, Sriramula S, Mariappan N, Agarwal D, Francis J

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