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Deficient cortisol production characterizes Addison's disease (fatigue, low blood pressure, hyperpigmentation)

Common side effects are typically mild and include temporary nausea, decreased appetite, and digestive changes that usually resolve within the first few weeks

In subgroup analyses based on the drugs used in the control arms, the overall cancer risks were identical in the tirzepatide group compared to the placebo, insulin, and GLP-1RA groups

One study showed that more than half of clinical trials on flu and pneumococcal vaccines left immunocompromised people out, as did around 4 out of 10 of Covid-19 vaccine studies