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It is a violation of this balance that leads to an increase in pressure, due to which the blood supply to the eye is impaired and the load on the optic nerve increases

However, in case of the ASCT2, studies showed that cysteine is actually a competitive inhibitor and not a substrate for ASCT2 ( Figure 1 via Multidrug Resistance Protein 1 exporter (MRP1), is cleaved extracellularly by -Glutamyl transferase (GGT) forming -Glutamyl-X substrate and Cysteinyl-Glycine

Centers for Disease Control and Prevention

Further studies are required to decipher the complex regulation of expression of different isoforms of the AsA-GSH pathway enzymes in order to bolster our understanding of ROS homeostasis in plants

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