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In doing so, GSH becomes oxidized and converts to GSSG

Given the decrease in GPx3 that we observe in konzo affected children, a deeper investigation of possible genetic predispositions is thus warranted, as this has also been a long-standing theory within the research community

The neuroprotective efficacy of phytochemicals in maintaining brain health during aging is primarily attributed to multiple mechanisms, including AChE and MAO inhibition, antioxidative and anti-inflammatory activities, antithrombotic and anti-apoptotic properties, and the enhancement of neurotrophic signaling pathways (8)

Xue et al., 2022

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