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Description

One of the primary mechanisms by which HIF-1 exerts this control is through the induction of pyruvate dehydrogenase kinase 1 (PDK1), a mitochondrial enzyme that phosphorylates and inactivates pyruvate dehydrogenase (PDH)

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The medication works through a dual mechanism of action

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Age, body weight, and gender have been evaluated in pharmacokinetic studies

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