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This phenomenon results in an injury to the skin or the underlying tissue or organ termed a wound

Keeping HbA1c below 7% slows progression, and tighter control may allow repair processes, including peptide-supported repair, to operate effectively

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S1P is formed in two steps from ceramide by ceramidase converting it to sphingosine, which is then phosphorylated to S1P by sphingosine kinase 1 and 2 (SK1 and SK2)

3 Studies indicate women with PCOS are more than three times as likely to experience depressive symptoms and over six times more likely to experience anxiety symptoms than those without PCOS