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Taken together with the findings that utilization of esketamine as an antidepressant increases LAC levels [59], the fact that the decrease in LAC levels in subjects with MDD is independent of psychotropic drug treatment raises the possibility that increasing LAC levels may be needed to induce antidepressant effects

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This leads to the immediate release of cAMP and the eventual downstream release of calcium and -arrestin

The medication has a half-life of approximately one week, meaning it remains in your system for an extended period after each injection