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http : .org/10.1007/s 10803-008-0591-5 72

Preclinical studies in Alzheimers mouse models, aged rats, and aged rhesus monkeys showed BDNF gene therapy prevented neuronal death, stimulated synaptic function, and improved memory

32 Since the partial 5UTR of p70S6K1 mRNA forms a secondary structure with the free energy of 82.30 kcal/mol, it is most likely that Pdcd4 inhibits the p70S6K1 translation via repressing eIF4A activity