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PMID 19699272

In the chronic injury microenvironment, DAMPs such as fibrinogen induce the expression of arginase 1 (Arg1) and IL-10 through the integrin signaling pathway, promoting the conversion of macrophages toward the M2 phenotype to support tissue repair (Wynn et al., 2013) (193)

Counterintuitively, we observed a strong negative correlation between the concentration of H 2 O 2 used in the pretreatment and the response of the matrix Grx1roGFP2 to the subsequent bolus of 1 mM exogenous H 2 O 2 (Fig 4B

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Recent studies have also found promise for the compound in studies evaluating it for MS, various drug-induced cell damage, and traumatic brain injuries