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Conjugation can be either enzymic or non-enzymatic, nevertheless, GSH transferases are widespread in both animals and plants, and enzymatic conjugation is assumed to be particularly effective and may even result in GSH depletion

Sikiric et al., 2001

When free radical production outpaces the body's antioxidant defenses a state known as oxidative stress cells accumulate damage that affects energy, immunity, skin health, and accelerates biological aging

Genes linked to tissue destruction and fibrosis are suppressed

In GMCs, CHOP is linked to the expression of collagen-related factors such as Col1a2, TGF-1, and Col1a4, which promote the synthesis of collagen in DKD