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Loren Pickart, who noticed that older blood lost its ability to stimulate tissue repair compared to younger blood and traced the difference back to this small peptide-copper complex

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In a rat model of DOX-induced cardiotoxicity, it has been unequivocally demonstrated that DOX induces the production of ROS and transforming growth factor-beta (TGF-), thereby promoting the transformation of cardiac fibroblasts into myofibroblasts (Cappetta et al., 2016)

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