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Initially, TGF- binds to TGF- receptor II (TRII), which then recruits and phosphorylates TGF- receptor I (TRI), leading to the activation of transcription factors Smad2 and Smad3
Gentry EG, Henderson BW, Arrant AE, Gearing M, Feng Y, Riddle NC, Herskowitz JH (2016) Rho Kinase Inhibition as a Therapeutic for Progressive Supranuclear Palsy and Corticobasal Degeneration
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doi: 10.1016/j.mrfmmm.2011.10.008 261
Slides were exposed to Hoechst nuclear staining (Invitrogen, 1:2000), before being sealed with Aqua-Poly/Mount (Polysciences) and glass covers
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