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Before initiating treatment with GLP-1 receptor agonists, healthcare professionals should consider obtaining baseline liver function tests (LFTs) , including ALT, AST, alkaline phosphatase (ALP), and bilirubin, particularly in patients with risk factors for liver disease

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Since the myelin sheath that protects nerve cells is in continual flux the methylmalonyl-CoA-induced inhibition of fatty acid synthesis results in the eventual destruction of the sheath