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mBio 13 , e0123922 (2022)

During the 5-day navigation phase of the MWM test, all the mice tended to have shorter escape time and distance

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Although multiple groups defined NOD presentation within this 3-year timeframe (90), potentially narrowing the window of opportunity for early intervention

3.2 Lipid accumulation Lipid accumulation is a common feature in the tubular cells of patients with DKD ( Lipotoxicity in renal TECs is associated with inflammation, oxidative stress, mitochondrial dysfunction and cell death ( Hypercholesterolemia also results in lipid deposition in kidney tissue, further compromising oxygen delivery through diffusion ( 3.3 Hypoxia Renal hypoxia has been observed in animal models of diabetes ( The enormous oxygen consumption in the kidneys is largely due to tubular reabsorption