The 4mg dose produced an average weight loss of 17.1% at 48 weeks in the clinical trial
Nausea, vomiting, or constipation caused by GLP-1 therapy may alter food intake patterns and vitamin K absorption, which is critical for warfarin users

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Finally, to confirm whether metformin also increased GLUT1 expression in the human intestine, human intestinal organoids were treated with metformin, and GLUT1 expression was compared
This was associated with changes in serum glucose levels but not serum cholesterol levels (Fig