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Also, the stronger absorption can increase the possibility of side effects (though DSIPs side-effect profile remains modestly characterized)

Approximately 70% to 90% of vitamin C is absorbed in moderate intakes of 30 to180 mg/day

This allows it to cross cell membranes intact, where it is converted into active glutathione inside the cell

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As OxS plays an important role in PSC activation and pancreatic fibrosis, we hypothesized that high glucose could stimulate pancreatic cells to produce excess ROS and activate PSCs, that induce pancreatic fibrosis and ultimately lead to -cell failure