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Research has focused on intestinal epithelial cells, immune cells, colitis models, mucosal healing concepts, and inflammatory signaling pathways such as NF-kB and MAPK

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Therefore, drug delivery targeting the extracellular region of target receptors faces several insurmountable challenges, including (1) competitive interference from endogenous ligands or antibodies at the target and (2) pseudotarget or target loss caused by shedding or mutation of the extracellular region, which significantly inhibits drug efficacy and may pose safety concerns