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Although the number of published studies is still limited, the integration of patient derived primary cells and organoids into OoC systems is emerging as a powerful approach to advance personalized therapy design and mechanistic disease investigation (145)

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Another theory posits that the distress associated with a cancer diagnosis may contribute to altered cognitive function and eventually lead to depression and anxiety (Hess 2007)

Pregnant women, nursing mothers, and individuals undergoing active chemotherapy should always avoid starting new protocols

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