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Vitamin B12 is generally considered safe and non-toxic, even at high doses, because it is water-soluble

Kreider RB, Kalman DS, Antonio J, Ziegenfuss TN, Wildman R, Collins R, Candow DG, Kleiner SM, Almada AL, Lopez HL

10.3109/09546631003801619 Wahab S, Anwar AI, Zainuddin AN, Hutabarat EN, Anwar AA, Kurniadi I: Combination of topical and oral glutathione as a skin-whitening agent: a double-blind randomized controlled clinical trial

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Recent evidence also indicates a possible crosstalk between apoptosis and ferroptosis, especially through the induction of ER stress [41, 42]