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Initially, it had been postulated that microbial changes have insignificant effects on tumour susceptibility, especially PC, and that tweaking the microbiome structure or composition does not affect the poor prognosis of PC patients (170)

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In diabetic nephropathy models, the AS-IV group showed significantly reduced expressions of GRP78 and IRE-1, key ERS regulators, resulting in suppression of NF-B/NLRP3 pathway activation, downregulation of NF-B p65 and IL-1, and subsequent inflammation and podocyte apoptosis mitigation in diabetic nephropathy rats (Sun et al., 2024)

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76 Since oxidative stress and inflammation have been suggested to play a role in the pathology and progression of CKD and its comorbidities (such as diabetes), antioxidants are being utilized in managing kidney diseases