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(2008) Opioids and the management of chronic severe pain in the elderly: consensus statement of an International Expert Panel with focus on the six clinically most often used World Health Organization Step III opioids (buprenorphine, fentanyl, hydromorphone, methadone, morphine, oxycodone)

86A , 983987 (2004)

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These activated fibroblasts also drive chronic persistent inflammation via the secretion and expression of pro-angiogenic and pro-inflammatory cytokines and chemokines [9], which promote the recruitment of inflammatory immune cells [10]

In rare cases, more serious risks can occur, such as pancreatitis, acute kidney injury, gallbladder issues