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In humans, the biosynthesis of 13-HODE requires LOX enzymes, glutathione peroxidases 39,61,62,63 , or non-enzymatic processes 39,64

doi:10.1097/AUD.0000000000001250

Frequency: Administer one subcutaneous injection daily for length of cycle

Reithmeier showed in 1987 that the structure of another calcium-binding protein, calsequestrin (which binds 40-50 calcium ions and is characterized by high levels of acidic residues), is calcium-sensitive as well, as this protein was rapidly degraded by trypsin in the absence of calcium, but showed remarkable stability in calcium-loaded form (Ohnishi and Reithmeier, 1987)

This paradox is not fully explained