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In human vascular smooth muscle cells, we could show that sDPP4 activates the MAPK and NF-B signaling cascade resulting in pro-atherogenic changes in human vascular smooth muscle cells illustrated by an increased proliferation, the induction of iNOS and elevated expression, and secretion of pro-inflammatory cytokines (208)

If you need it just for weight loss: You will find a better option with the higher doses of Tirzepatide