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Taken together, these findings suggest that Nrf2 plays a vital role in mediating the chondroprotective effects of metformin by means of anti-oxidation, and that loss of Nrf2 substantially attenuates, but does not completely abolish, the therapeutic efficacy of metformin in the MIA-induced OA model

For anyone following this field, the existing evidence offers a compelling scientific rationale for that investment, while demanding the intellectual honesty to acknowledge how much remains unknown

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A warm or flushing sensation near the injection area